Association of Myelin Content in Lesions and Cognition in MS
February 11, 2022
Cognitive impairment is highly prevalent in patients with multiple sclerosis and mechanisms of cognitive decline remain poorly understood.Our group conducted a study of patients with MS to study myelin content in brain lesions and cognition in MS.One hundred and sixty-four MS patients underwent MRIs using a specialized sequence that measures myelin content in lesions. These patients also had cognitive assessment using a test called SDMT, which is a good test of information processing speed...
Exploring mRNA Vaccines for the treatment of MS
March 5, 2021
The COVID-19 vaccinations have served to bring the world's attention to mRNA vaccines!mRNA vaccine technology is an exciting new avenue for treatment of autoimmune conditions with far reaching implications Recently researchers published results from a study exploring the potential benefits of mRNA vaccination as a treatment modality in mouse models of MS. In autoimmune diseases like MS, breach of immune tolerance and self injury caused by ones own immune cells lead to disease. This injury is...
AGING AND MS
February 4, 2021
We cannot stop aging! It also changes your multiple sclerosis in important ways that we rarely discuss.Our brains continue to grow until age of 13 and continue to myelinate until late 20s. After that all of us begin to lose some neurons and connections in white matter and synapses but multiple sclerosis patients experience this at younger age and faster rate due to their prior loss of connectivity.Our brain and spinal cord reserve decreases with age and the ability to recover form relapses is...
