Potential new medication for progressive MS shows promise in early trial
July 25, 2018
While the treatment armamentarium for MS has vastly expanded in the last decade and continues to grow, these treatments have been predominantly for the relapsing forms of the disease, and effective treatments for progressive MS remain a glaring need.Ibudilast (MN-166, MediciNova) is a phosphodiesterase inhibitor with anti-inflammatory properties and potentially neuroprotective activity as well, which was tested in a Phase 2 trial of progressive MS patients.Ibudilast has been marketed in Japan...
Exploring mechanisms of disease progression
July 25, 2018
Dr. Susan Gauthier’s research passion lies in uncovering the underlying principles that govern disease progression in Multiple Sclerosis (MS). Despite potent anti-inflammatory treatment and other strides in MS, predicting a patient’s disease progression still eludes us. Furthermore, there has been very little impact on altering the clinical course of MS once patients enter the progressive phase.Her research focuses on exploring two main hypotheses on why people may progress:Years of loss of...
Digital Ed
December 14, 2017
By Amy CrawfordPhotos by John AbbottIllustration by Alexander VidalBrain and Behavior, a required course for students in the fall of their second year, covers a wide range of topics—from basic neuroscience to diseases of the central nervous system and the physiology of mental illness. As in any medical school course, it comprises a staggering amount of information, and absorbing it all can be a challenge. But Lee Gottesdiener ’19 says the details of one disease—multiple sclerosis (MS)—are...
