After one year of administering a cognitive assessment to 157 patients with multiple sclerosis at Weill Cornell Medicine, we found a relationship between a certain lesion type, known as a rim-positive lesion, and cognition.
Based on our prior studies, it is thought that this lesion type represents more active disease due to the increased presence of inflammatory cell types. Our data found that approximately 36% of patients had this lesion type on MRI. Of these patients, those who had an increased number of total lesions demonstrated worse performance on physician disability, verbal memory, and information processing speed assessments.
We are excited to continue working with patients on this study in order to further understand the progression of disease in relation to disability and lesion type.
This study was conducted by researchers including the author at the Imaging lab of Dr Susan Gauthier.
Melanie Marcille
Here is a link to the article on pubmed: https://pubmed.ncbi.nlm.nih.gov/35292734/