Adjust, Adapt and Accept with Grace
April 16, 2026
Adjust, Adapt and Accept with Grace.This is the mantra I try to live with; operative word being “try” and not always successfully.I chased a diagnosis for 20 years; from my mid 40’s to my mid 60’s. MS was just not on anyone’s radar. The journey to diagnosis included a surprise finding in 2015; a syrinx on my spine. The doctor who found it was gleeful. He found (or so he thought) the reason for the increasing weakening in my left leg. The surgeon who actually put in the required shunt threw his...
Progressive Multiple Sclerosis – A focus on three therapies
April 16, 2026
1. BTK InhibitorsBruton tyrosine kinase (BTK) is an enzyme that plays a crucial role in the survival and function of B-cells. B-cells or B lymphocytes play a critical role in the pathogenesis of multiple sclerosis. By blocking BTK , these medications work by preventing their multiplication and actions. BTK is also associated with other immune cells like macrophages and microglia present in the brain which can play a role in worsening disability in progressive MS. Several BTK inhibitors were...
Understanding MS Relapse Versus Pseudo-Relapse – and When to Call Your MS Care Team
March 16, 2026
Experiencing a sudden change in symptoms can be unsettling, but it’s important to know that not every worsening of symptoms represents a true MS relapse. A true relapse reflects new inflammatory activity in the central nervous system and causes new neurologic symptoms or a clear worsening of previous ones that persist for at least 24–48 hours, without another explanation such as infection or fever. These relapses often correspond with new lesions seen on MRI and may sometimes require treatment...
