Pregnancy and Infant Outcomes in Women With Multiple Sclerosis Treated With Ocrelizumab
May 15, 2026
Ocrelizumab has now become one of the most commonly used disease modifying therapies (DMT) for treatment of multiple sclerosis (MS). It is a high-efficacy treatment targeting a specific type of immune cell in the body, called anti-CD20 B cells. These cells can be commonly found in peripheral nervous system, as well as brain tissue and cerebrospinal fluid (CSF). Multiple theories exist in how B cells play a key role in MS pathogenesis, and targeting of these cells decreases inflammation, which ...
Adjust, Adapt and Accept with Grace
April 16, 2026
Adjust, Adapt and Accept with Grace.This is the mantra I try to live with; operative word being “try” and not always successfully.I chased a diagnosis for 20 years; from my mid 40’s to my mid 60’s. MS was just not on anyone’s radar. The journey to diagnosis included a surprise finding in 2015; a syrinx on my spine. The doctor who found it was gleeful. He found (or so he thought) the reason for the increasing weakening in my left leg. The surgeon who actually put in the required shunt threw his...
Progressive Multiple Sclerosis – A focus on three therapies
April 16, 2026
1. BTK InhibitorsBruton tyrosine kinase (BTK) is an enzyme that plays a crucial role in the survival and function of B-cells. B-cells or B lymphocytes play a critical role in the pathogenesis of multiple sclerosis. By blocking BTK , these medications work by preventing their multiplication and actions. BTK is also associated with other immune cells like macrophages and microglia present in the brain which can play a role in worsening disability in progressive MS. Several BTK inhibitors were...
