Multiple Sclerosis and Genetics
August 2, 2023
On one hand many newly diagnosed multiple sclerosis (MS) patients ask why they are the first ones in their family with MS. On the other hand, we see patients where one or more family members have the disease. MS is not a classically inherited disease; however, the risk of developing MS is higher for siblings or children of a person with MS than for the general population. The lifetime risk of MS in first-degree relatives of MS patients is estimated at 3%. Important knowledge also comes from...
Anti-CD20 Therapies for African American Vs Caucasian Americans with Relapsing MS
June 9, 2023
We did a study to examine the efficacy of all B cell targeted therapies ( ocrelizumab, rituximab, ofatumumab) on AfricanAmerican MS (AAMS) patients and Caucasian American MS (CAMS) patients.I did this study under the mentorship of Dr Jai Perumal.
MOG Antibody-Associated Disease ( MOGAD)
May 10, 2023
Myelin Oligodendrocyte glycoprotein ( MOG) antibody associated disease is now being recognized as an unique entity different from multiple sclerosis and Neuromyelitis opticaIt is also a central nervous system inflammatory disease like MS and NMOIt is defined by high titers of serum MOG-AbCan have a monophasic or relapsing course.About 50 % of the time it is monophasic.Persistent high serum titers of MOG-ab increases the likelihood of having relapses.Characterized more commonly by presentation...
