Bruton Tyrosine Kinase Inhibitors (BTKi) in Multiple Sclerosis
October 15, 2025
BTKis target a group of proteins found on a variety of immune cells involved in the pathogenesis of Multiple Sclerosis (MS), including mediators of inflammation locally in the Central Nervous System (CNS). By targeting these proteins, the hope is that these medications will be able to decrease the activation of immune cells within the central nervous system directly, and could prevent inflammatory activity in people with MS. BTKis have several theoretical advantages over some of the current...
Beat the Heat?
September 15, 2025
When I was a kid, I didn’t really like summer. I preferred the structure of school, soccer practices and games, and playing with my friends. Summer meant day camp, seemingly endless days of lanyards and Red Rover, while my friends mostly went to sleepaway, which I never wanted to do. My own middle-schooler doesn’t believe that I wrote long letters to my best friend at camp in the Catskills, and she wrote long letters back, often in alternating colorful inks. One problem I did NOT have in these...
Review of “Remyelination of Chronic Demyelinated Lesions With Directly Induced Neural Stem Cells” Published in Brain (2025)
September 15, 2025
In the recent article “Remyelination of chronic demyelinated lesions with directly induced neural stem cells” published in Brain (2025), Dr. Luca Peruzzotti-Jametti, Dr. Stefano Pluchino, and colleagues from the University of Cambridge and international collaborators explore a novel stem cell-based strategy for repairing nerve damage in multiple sclerosis (MS). The study addresses a key challenge in progressive MS: the failure to repair myelin, which is the protective sheath around nerve fibers...
