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Clinical quantitative susceptibility mapping (QSM): Biometal imaging and its emerging roles in patient care.

TitleClinical quantitative susceptibility mapping (QSM): Biometal imaging and its emerging roles in patient care.
Publication TypeJournal Article
Year of Publication2017
AuthorsWang Y, Spincemaille P, Liu Z, Dimov A, Deh K, Li J, Zhang Y, Yao Y, Gillen KM, Wilman AH, Gupta A, Tsiouris AJohn, Kovanlikaya I, Chiang GChia-Yi, Weinsaft JW, Tanenbaum L, Chen W, Zhu W, Chang S, Lou M, Kopell BH, Kaplitt MG, Devos D, Hirai T, Huang X, Korogi Y, Shtilbans A, Jahng G-H, Pelletier D, Gauthier SA, Pitt D, Bush AI, Brittenham GM, Prince MR
JournalJ Magn Reson Imaging
Volume46
Issue4
Pagination951-971
Date Published2017 Oct
ISSN1522-2586
Abstract

Quantitative susceptibility mapping (QSM) has enabled magnetic resonance imaging (MRI) of tissue magnetic susceptibility to advance from simple qualitative detection of hypointense blooming artifacts to precise quantitative measurement of spatial biodistributions. QSM technology may be regarded to be sufficiently developed and validated to warrant wide dissemination for clinical applications of imaging isotropic susceptibility, which is dominated by metals in tissue, including iron and calcium. These biometals are highly regulated as vital participants in normal cellular biochemistry, and their dysregulations are manifested in a variety of pathologic processes. Therefore, QSM can be used to assess important tissue functions and disease. To facilitate QSM clinical translation, this review aims to organize pertinent information for implementing a robust automated QSM technique in routine MRI practice and to summarize available knowledge on diseases for which QSM can be used to improve patient care. In brief, QSM can be generated with postprocessing whenever gradient echo MRI is performed. QSM can be useful for diseases that involve neurodegeneration, inflammation, hemorrhage, abnormal oxygen consumption, substantial alterations in highly paramagnetic cellular iron, bone mineralization, or pathologic calcification; and for all disorders in which MRI diagnosis or surveillance requires contrast agent injection. Clinicians may consider integrating QSM into their routine imaging practices by including gradient echo sequences in all relevant MRI protocols.

LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2017;46:951-971.

DOI10.1002/jmri.25693
Alternate JournalJ Magn Reson Imaging
PubMed ID28295954
PubMed Central IDPMC5592126
Grant ListR01 CA181566 / CA / NCI NIH HHS / United States
R01 NS072370 / NS / NINDS NIH HHS / United States
R01 NS090464 / NS / NINDS NIH HHS / United States
R01 NS095562 / NS / NINDS NIH HHS / United States

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