MOG Antibody-Associated Disease ( MOGAD)

Myelin Oligodendrocyte glycoprotein ( MOG) antibody associated disease is now being recognized as an unique entity different from multiple sclerosis and Neuromyelitis optica

It is also a central nervous system inflammatory disease like MS and NMO

It is defined by high titers of serum MOG-Ab

Can have a monophasic or relapsing course.

About 50 % of the time it is monophasic.

Persistent high serum titers of MOG-ab increases the likelihood of having relapses.

Characterized more commonly by presentation of optic neuritis and transverse myelitis in adults.

Relaspes usually respond well to IV steroids

Unlike NMO or MS, there can be resolution of MRI abnormalities more commonly in MOG ab disease 

Long-term treatment is usually monthly IVIG , immune suppressive medications like Rituximab/cellcept can be considered 

Jai S Perumal MD

Weill Cornell Medicine Multiple Sclerosis Center 1305 York Ave., Second Floor New York, NY 10021